A 55-year-old man with a history of hypertension presents with dyspnea on exertion and orthopnea. Physical examination reveals bibasilar crackles, jugular venous distention, and a third heart sound. His ejection fraction is 30%. Which medication would be most appropriate to reduce mortality in this patient?

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TheoryPractice · Accepted Answer

ACE inhibitor. This patient has heart failure with reduced ejection fraction (HFrEF). ACE inhibitors have been shown to reduce mortality in patients with HFrEF and are first-line therapy along with beta-blockers. While loop diuretics improve symptoms, they have not been proven to reduce mortality.

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