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USMLE Step 2 CK Medical PrepQuestion 4 / 10

A 45-year-old man presents with new-onset chest pain that worsens with inspiration and improves when leaning forward. His ECG shows diffuse ST-segment elevation. What is the most likely diagnosis?

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✓ Correct answer: A. Acute pericarditis The clinical presentation of chest pain worsening with inspiration and improving when leaning forward, along with diffuse ST-segment elevation on ECG, is characteristic of acute pericarditis. This differs from acute MI, which typically shows ST elevation in specific coronary artery distribution.

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