A 30-year-old woman is 8 weeks pregnant and is prescribed isotretinoin for severe acne. Which of the following congenital malformations is most strongly associated with exposure to this medication during pregnancy?
Practise this USMLE Step 1 Medical Prep question free, then download the PDF, watch the video walkthrough, or unlock timed mock exams for the full web bank.
✓ Correct answer: B. Craniofacial abnormalitiesIsotretinoin (a vitamin A derivative) is a potent teratogen that causes characteristic craniofacial abnormalities, including ear malformations, micrognathia, and cleft palate. It also causes cardiac and CNS defects. This medication is contraindicated during pregnancy due to its high risk of causing congenital malformations.
Keep practising. Use the free USMLE Step 1 Medical Prep PDF, watch the YouTube walkthrough, or unlock all 10 web questions with timed mock exams.
Free practice here. Timed mocks when you are ready.
Study the USMLE Step 1 Medical Prep free question explanations, download the PDF, then unlock timed mock exams on the web when you want exam-day practice.
Theory