A 68-year-old patient with a sulfa allergy is prescribed furosemide. Which counseling point is most pharmacologically relevant to this allergy history?

A 68-year-old patient with a sulfa allergy

Multiple choice — select the best answer

AFurosemide is a sulfonamide-based loop diuretic, so cross-reactivity with sulfa antibiotics is theoretically possible and should be discussed with the prescriber
BAll loop diuretics are absolutely contraindicated in patients with sulfa allergies
CFurosemide should be replaced with a thiazide diuretic, which has no sulfonamide structure
DFurosemide does not contain any sulfonamide moiety and can be given safely without concern

✓ Correct answer: A. Furosemide is a sulfonamide-based loop diuretic, so cross-reactivity with sulfa antibiotics is theoretically possible and should be discussed with the prescriber Furosemide contains a sulfonamide group; while the clinical significance of cross-reactivity is debated, the prescriber should be aware of the sulfa allergy so an informed benefit-risk decision can be made before dispensing.

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A 68-year-old patient with a sulfa allergy is prescribed furosemide. Which counseling point is most pharmacologically relevant to this allergy history?

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