Mutations to p53 that interfere with DNA binding are most likely to result in

Mutations to p53 that interfere with DNA

Multiple choice — select the best answer

AUpregulation of p21 expression and an increase in CDK-dependent phosphorylation.
BDownregulation of p21 expression and a decrease in CDK-dependent phosphorylation.
CUpregulation of p21 expression and a decrease in CDK-dependent phosphorylation.
DDownregulation of p21 expression and an increase in CDK-dependent phosphorylation.

✓ Correct answer: D. Downregulation of p21 expression and an increase in CDK-dependent phosphorylation. p53 regulates p21 expression, increasing p21 expression when it detects damaged DNA. An inability of p53 to bind to DNA would downregulate p21 expression levels. p21, in turn, binds to cyclins, preventing activation of CDK-dependent phosphorylation.

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