Which maternal-infant blood group combination is most likely to result in neonatal jaundice due to blood group incompatibility?
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AMother with A-positive blood and infant with B-negative blood
BMother with B-negative blood and infant with B-positive blood
CMother with AB-negative blood and infant with A-positive blood
DMother with O-positive blood and infant with B-positive blood
✓ Correct answer: D. Mother with O-positive blood and infant with B-positive bloodAnswer: Mother with O-positive blood and infant with B-positive blood. ABO incompatibility typically occurs when mothers with blood group O (absence of antigen) have infants with blood group A or B. This condition is the most frequent cause of hemolytic disease in newborns after the usage of RhoGAM to prevent Rh incompatibility. Mothers with blood group O have naturally occurring anti-A and anti-B (IgG) antibodies, which lead to neonatal jaundice (hyperbilirubinemia) in a variable and generally milder form compared to Rh incompatibility. Although 15% of all pregnancies involve possible ABO incompatibility, only a subset shows significant hemolysis and hyperbilirubinemia.
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