Why are NSAIDs such as carprofen generally avoided in patients that are dehydrated or hypotensive?

Why are NSAIDs such as carprofen generally

Multiple choice — select the best answer

AThey raise blood glucose dangerously
BThey cause immediate hyperkalemia
CThey are inactivated by gastric acid
DReduced prostaglandins impair renal perfusion, risking kidney injury

✓ Correct answer: D. Reduced prostaglandins impair renal perfusion, risking kidney injury NSAIDs inhibit prostaglandins that maintain renal blood flow; in a volume-depleted patient this can precipitate acute kidney injury.

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Topic: Pharmacology & Pharmacy

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Why are NSAIDs such as carprofen generally avoided in patients that are dehydrated or hypotensive?

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