The dietitian is discussing with a client why the endocrinologist has recommended adding a GLP-1 agonist to their current metformin therapy. The dietitian knows:
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AThe addition of a basal insulin helps to improve glycemic control primarily during meals with less risk of hypoglycemia
BBoth postprandial and fasting glucose levels are generally elevated in most individuals with type 2 diabetes
COnly fasting glucose levels typically worsen in individuals with type 2 diabetes who are untreated with medication
DMetformin only addresses the postprandial hyperglycemia
✓ Correct answer: B. Both postprandial and fasting glucose levels are generally elevated in most individuals with type 2 diabetesAnswer: Both postprandial and fasting glucose levels are generally elevated in most individuals with type 2 diabetes. Both overnight and between-meal glucose levels (fasting or basal) and the increments above pre-meal levels (postprandial) are increased in most people with diabetes, and both components of hyperglycemia typically worsen with increasing duration of diabetes. Both components, basal and postprandial, worsen with the increasing duration of diabetes. Metformin acts mainly on fasting and between-meal hyperglycemia, not on postprandial hyperglycemia. The addition of a GLP-1 agonist can help to improve glycemic control by addressing both postprandial and fasting glucose levels.
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Theory